門脈圧亢進症患者のトリプトファン代謝にかんする研究
1964 年 30 巻 3 号 p. 208-212
詳細
1964 年 30 巻 3 号 p. 208-212
Two g of L-tryptophan was administered per os to patients of portal hyperension, who were classified to 2nd and 3rd groups by Imanaga, and tryptophan, kynurenine, kynureninic acid, xanthurenic acid and N-methylpyridone carboxamide in 24 hours urine were determined. It was revealed that the excretion of these tryptophan metabolites of the 2nd group was similar to that of normal, while in the 3rd group, the increased excretions of xanthurenic acid and N-methylpyridone carboxamide were observed. Therefore, the convertion rate of typrophan is supposed to be higher in the patents of 3rd group. The excretion of tryptophan metabolites was not changed before and after the portocaval end-to-side anastomosis, except just after the operation.
