諸種Coenzyme Q化合物投与後の肝Conzyme Q含有量の動向
1965 年 32 巻 6 号 p. 566-569
詳細
1965 年 32 巻 6 号 p. 566-569
The CoQ content in the liver was examined after the administeration of various CoQ compounds to male albino rats. Of five CoQ compounds, CoQ_2,CoQ_6,CoQ_7,CoQ_9 and CoQ_<10>, only CoQ_7,CoQ_9 and CoQ_<10> raised the CoQ content after giving it intramuscularly in surfactant solution two times daily beforehand. After cell fractionation these increments of CoQ content were found mainly in the other fraction except mitochondria, but CoQ_9 and CoQ_7 raised it in mitochondria, too. In the rats with acute CCl_4 poisoning, the administration of CoQ_9 increased the CoQ content in the liver and its mitochondria more than that of CoQ_7 did. The paperchromatography of CoQ compounds in liver mitochondria showed that a corresponding CoQ increased respectively after the administration of various CoQ compounds.
