Hydroxyethylthiamine同族体およびこれらのDiacyl誘導体の合成 : ビタミンB_1および諸関係化合物の研究(CV)
1965 年 32 巻 6 号 p. 570-575
詳細
1965 年 32 巻 6 号 p. 570-575
Some experimental conditions were described on the reaction between thiamine and aldehydes affording hydroxyethylthiamine (HET) or its homologs. It was found that, as discribed by Miller and his coworkers, the best yield was attained when thiamine chloride hydrochloride was treated with 1.8-2.0 equivalents of alkali, and reacted with 20-40 equimolecular amount of aldehydes at 50-60℃ for about 3 hours. Several diacylated derivatives of HET and its homologs were synthesised by the reaction with acyl chlorides in acidic conditions.
