Thiamine disulfideにかんする研究 : (XXII)Thiamine disulfide誘導体の経口吸収にみられる動物差

抄録

TDS, BTDS, BuTDS, iBuTDS and thiamine were orally administrated to man, rabbit and rat, and the intestinal absorption was statistically compared by urinary thiamine excretion or blood thiamine level. The urinary excretion for 24 or 48 hrs was not so much differed among these derivatives in rabbit, however, profound differences were observed in man. BTDS, having aromatic acyl groups, was shown to have the higher absorbability than that of BuTDS and iBuTDS, having aliphatic acyl groups. Thiamine and TDS, of fundamental structure, were only poorly absorbed giving the urinary excretion of one tenth or twentieth of acyl-TDS. In rat the similar tendency was also observed as in the case of man. The structure-activity correlation and species difference in the vitamin absorption were shortly discussed.