抄録
Initial amount of TAD incorporated into erythrocytes in vitro was found to be proportional to the logarism of second order reaction rate constant between the derivatives and GSH, suggesting some limiting effect of the intracellular reduction process. Extracellular reduction of TAD was caused by an exchange reaction of TAD and alkylmercaptan, which was produced in the cells and breaked out ; the mechanism was obviously different from that of acyl-TDS (outflux of O-acylthiamine). Some model experiments were carried out, using n-hexane or liquid paraffin emulsion as lipid barrier and GSH as intracellular thiols.
