抄録
To clarify the fat metabolism as related to thiamine and magnesium, six different synthetic diets were given to Wistar rats for two or four weeks. Group I, thiamine and magnesium deficient ; group II, thiamine deficient, magnesium sufficient ; group III, thiamine adequate, magnesium deficient ; group IV, thiamine adequate, magnesium sufficient ; group V, thiamine excess, magnesium deficient ; group VI, thiamine excess, magnesium sufficient, After 2-or 4-week period on these dietary regimens, ^<14>C-acetate or ^<14>C-glucose was administered. Ninety minutes after labeled compound was given, rats were sacrificed. Triglyceride, cholesterol and total lipid levels in the livers of groups III and V increased significantly. These values decreased in groups I and II. Incorporation of ^<14>C-acetate or ^<14>C-glucose into liver lipid or cholesterol fractions increased in magnesium deficient groups (groups III and V) rather than in the magnesium sufficient groups (groups IV and VI). This increase was most prominent in the thiamine deficient groups (groups I and II), although total lipid and total cholesterol levels in the liver decreased in these groups. A possible explanation of the mechanism is presented.
