巻号一覧
48 巻, 1 号
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糸川 嘉則原稿種別: 本文
1974 年 48 巻 1 号 p. 1-8
発行日: 1974/01/25
公開日: 2018/03/02
ジャーナル フリーTo clarify the fat metabolism as related to thiamine and magnesium, six different synthetic diets were given to Wistar rats for two or four weeks. Group I, thiamine and magnesium deficient ; group II, thiamine deficient, magnesium sufficient ; group III, thiamine adequate, magnesium deficient ; group IV, thiamine adequate, magnesium sufficient ; group V, thiamine excess, magnesium deficient ; group VI, thiamine excess, magnesium sufficient, After 2-or 4-week period on these dietary regimens, ^<14>C-acetate or ^<14>C-glucose was administered. Ninety minutes after labeled compound was given, rats were sacrificed. Triglyceride, cholesterol and total lipid levels in the livers of groups III and V increased significantly. These values decreased in groups I and II. Incorporation of ^<14>C-acetate or ^<14>C-glucose into liver lipid or cholesterol fractions increased in magnesium deficient groups (groups III and V) rather than in the magnesium sufficient groups (groups IV and VI). This increase was most prominent in the thiamine deficient groups (groups I and II), although total lipid and total cholesterol levels in the liver decreased in these groups. A possible explanation of the mechanism is presented.抄録全体を表示PDF形式でダウンロード (670K) -
高島 雍治, 古谷 充子, 生田 政裕, 和志武 三徳, 田中 一郎, 太幡 利一原稿種別: 本文
1974 年 48 巻 1 号 p. 9-17
発行日: 1974/01/25
公開日: 2018/03/02
ジャーナル フリーIn the previous paper, the influence of water contents on the stability of vitamin A aldehyde in aqueous ethanolic solutions was reported. Similar investigations were carried out on vitamin A aldehyde in various alcohols and other water soluble organic solvents, and the results are discribed in this paper. Vitamin A aldehyde solutions in absolute or 80% aqueous solvents were stored at 50℃. The remaining rates of vitamin A aldehyde and the yield of vitamin A acetal were estimated by spectrophotometric methods. Vitamin A aldehyde was stable in 80% aqueous alcoholic solution (in isopropanol, n-propanol, ethanol and methanol). Vitamin A aldehyde was converted into vitamin A acetal in absolute methanol, ethanol and n-propanol, whereas it was not converted in absolute isopropanol. Vitamin A aldehyde was more stable in absolute dioxane and tetrahydrofurane than in the corresponding 80% aqueous solvents. In dimethylformamide, vitamin A aldehyde was stable in both absolute and 80% aqueous solvents. Properties of vitamin A acetal prepared in absolute methanol were examined by mass, NMR and IR spectrometry. In absolute methanolic solution, the majority of vitamin A aldehyde was converted into vitamin A acetal after 14 days at 50℃. In 80% aqueous methanolic solution, vitamin A acetal was rapidly reversed into vitamin A aldehyde.抄録全体を表示PDF形式でダウンロード (651K) -
満田 久輝, 滝井 幸男, 田中 孝男原稿種別: 本文
1974 年 48 巻 1 号 p. 19-24
発行日: 1974/01/25
公開日: 2018/03/02
ジャーナル フリーGrowth of tobacco (Nicotiana tabacuum var. Bright Yellow) callus depended on an exogenous supply of thiamine or its phosphate lester in a culture medium. The growth was found maximum at the concentration of 10^<-6>M of the vitamin in the medium, above the concentration, however the growth was slightly retarded. Oxythiamine (5-(2-hydroxyethyl)-3-[(4-hydroxy-2-methyl-5-pyrimidinyl) methyl]-4-methylthiazolium chloride) and deaminothiamine (5-(2-hydroxyethyl)-3-[(2-methyl-5-pyrimidinyl) methyl]-4-methylthiazolium perchlorate) inhibited the growth of the callus cultured in the medium containing a limited amount of thiamine, and the inhibitory effect of these compounds was competed by a further supplementation of thiamine which could recover a normal growth. A mixture of pyrimidine (2-methyl-4-amino-5-hydroxymethylpyrimidine) and thiazole (4-methyl-5-β-hydroxyethylthiazole) moieties of thiamine was revealed to satisfy fully the requirement, the growth of the callus being associated with a significant increase in the contents of thiamine in the cells. In the absence of the thiazole, the pyrimidine did not show any significant growth effect. On the other hand, the thiazole alone could support the growth of the callus which was preliminarily cultured for 17 days in the thiaminedeficient medium. These results lead to the suggestion that thiamine is synthesized in vivo from the pyrimidine and the thiazole moieties in the tobacco callus as well as in plants and in microorganisms, and that the biosynthetic pathway of the thiazole is defective in the callus cells.抄録全体を表示PDF形式でダウンロード (618K)
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