ビタミン
Online ISSN : 2424-080X
Print ISSN : 0006-386X
2-Butylthiothiamine の合成と Saccharomyces に対する増殖阻害作用
橋爪 清松戸田 千登世安井 照代永納 秀男
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ジャーナル フリー

1987 年 61 巻 12 号 p. 611-616

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抄録
4-Amino-2-butylthio-5-hydroxymethylpyrimidine (3) corresponding to the 2-subst,ituted pyrimidine moiety in thiamine was prepared from ethyl ethoxy-methylenemalonate in an overall yield of 46.7% in 4 steps. This product was chlorinated with thionyl chloride followed by condensation with 4-methyl-5-(β-hydroxyethyl)thiazole in dioxane to give 2-butylthiothiamine (2). The inhibitory effect of (2), (3) and 2-methylthiothiamine (1) on the growth of Saccharomyces carlsbergensis was examined under the following three culture conditions: a) vitamin B_1 and B_6 free medium, b) B_6 supplemented medium, and c) both B_1 and B_6 supplemented medium. Both compounds inhibited the growth of S. carlsbergensis under these conditions, the order of inhibitory po-tency being a) (1)>(3)>(2), b) (1)>(2)>(3), and c) (2)≧(1)>(3).
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© 1987 日本ビタミン学会

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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