抄録
The body weight, liver weight, contents of thiobarbituric acid-reactive substances, flavins and glutathione in the liver, activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase in the liver cytosol fraction, and activities of GOT and GPT in the serum of mice were measured at 24 hours after administration of ethanol as parameters of the acute alcoholic liver injury. In the groups of administration of 86.0 or 103.2 mmol/kg of ethanol, the acute alcoholic liver injury was recognized. When administered 0.19 mmol/kg or riboflavin, flavin mononucleotide, or flavin adenine dinucleotide (FAD) to mice suffered from the acute alcoholic liver injury caused by the administration of 86.0 mmol/kg of ethanol, the suppressive effect of each flavin was recognized and FAD worked most effectively. We considered that the acute alcoholic liver injury was related to the lipid peroxidation and that it was suppressed by the administration of FAD.
