抄録
L-Ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative, stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissue (dermis) by skin fibroblasts. Investigation of molecular mechanisms of Asc 2-P action indicated that it stimulates maturation of extracellular matrix (ECM) by activating transcription of genes for type I collagen which form a back-bone structure of the ECM. Asc 2-P also stimulates differentiation and maintains differentiated phenotypes of various kinds of cells of epithelial and mesenchymal origin. Asc 2-P may be useful to clarify new physiological functions of vitamin C and investigation of the molecular mechanisms.
