ビタミン
Online ISSN : 2424-080X
Print ISSN : 0006-386X
疾患におけるビタミンE濃度調節機構(<特集>第65回大会シンポジウム「ビタミン研究の新しい息吹」)
瀧谷 公隆
著者情報
ジャーナル フリー

2013 年 87 巻 12 号 p. 678-684

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抄録
Vitamin E has an important role for prevention against lipid peroxidation in several pathological conditions. α-Tocopherol transfer protein (α-TTP) binds selectively α-tocopherol, and regulates α-tocopherol levels in the plasma. Moreover, α-TTP is known to play a critical role in the maintenance of pregnancy and in protecting against lipid peroxidation in the central nervous system. However, there are few reports regarding the regulation of α-TTP expression. We have conducted the promoter analysis of human α-TTP gene, and have examined vitamin E status and α-TTP expression in several pathological conditions including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Human α-TTP gene is transcriptionally regulated through liver X receptor (LXR) signaling, which is a member of nuclear receptor superfamily and modulates lipid metabolism and energy metabolism. Hepatic α-TTP expression was altered in pathological conditions including type 2 diabetes and NAFLD, and might affect α-tocopherol status. Investigation of the regulation of α-TTP expression may contribute to further clarification of vitamin E status in pathological conditions and further understanding of the antioxidant mechanisms of vitamin E.
著者関連情報
© 2013 日本ビタミン学会

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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