Abstract
Chronic low-grade inflammation (CLI) is induced by immune system dysregulation occurring with aging. The systemic CLI process presented in elderly individuals is a critical etiological component of physiological decline and risk factor for age-related diseases such as atherosclerosis and other cardiovascular diseases; metabolic syndrome, type 2 diabetes, and obesity; sarcopenia and osteoporosis; neurodegeneration; major depression and impaired mental wellbeing; and cancer. Achieving CLI attenuation or prevention with nutrients could be an important strategy to reduce incidence or severity of age-related functional decline and diseases. This review focusses on omega-3 fatty acids, probiotics, vitamin D, polyphenols, and tryptophan which function as possible nutritional strategies to reduce CLI. CLI enhances not only immunosenescence occurring with aging, but also the process of aging. Therefore, the combined use of these nutrients may be important and effective in overcoming CLI and its related diseases.
