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Volume 97, Issue 5-6
Displaying 1-14 of 14 articles from this issue
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[in Japanese]2023 Volume 97 Issue 5-6 Pages 247-256
Published: June 25, 2023
Released on J-STAGE: June 30, 2024
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Eiji Takeda, Manami Iwase2023 Volume 97 Issue 5-6 Pages 257-270
Published: June 25, 2023
Released on J-STAGE: June 30, 2024
JOURNAL OPEN ACCESSChronic low-grade inflammation (CLI) is induced by immune system dysregulation occurring with aging. The systemic CLI process presented in elderly individuals is a critical etiological component of physiological decline and risk factor for age-related diseases such as atherosclerosis and other cardiovascular diseases; metabolic syndrome, type 2 diabetes, and obesity; sarcopenia and osteoporosis; neurodegeneration; major depression and impaired mental wellbeing; and cancer. Achieving CLI attenuation or prevention with nutrients could be an important strategy to reduce incidence or severity of age-related functional decline and diseases. This review focusses on omega-3 fatty acids, probiotics, vitamin D, polyphenols, and tryptophan which function as possible nutritional strategies to reduce CLI. CLI enhances not only immunosenescence occurring with aging, but also the process of aging. Therefore, the combined use of these nutrients may be important and effective in overcoming CLI and its related diseases.View full abstractDownload PDF (1314K) -
Yoshihiro Mezaki2023 Volume 97 Issue 5-6 Pages 271-274
Published: June 25, 2023
Released on J-STAGE: June 30, 2024
JOURNAL OPEN ACCESSLiver cells can be divided into parenchymal cells (hepatocytes) and non-parenchymal cells. The latter cells include Kupffer cells (KCs), pit cells, hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs). LSECs comprise the sinusoid, a specialized capillary which has small fenestrations (100 to 150 nm in diameter) in their thin walls. Due to the absence of a basement membrane lining LSECs, small particles and solutes within the blood can pass through the fenestrations freely. Chylomicron (CM) is a large lipoprotein (80 to 1,000 nm in diameter) secreted from intestinal absorptive epithelial cells. During circulation, triglycerides in CM are degraded by lipoprotein lipase and the residual lipoprotein forms a chylomicron remnant (CMR) with a diameter of 30 to 80 nm, which can pass through LSEC fenestrations to reach the hepatocytes. Absorbed vitamin A is incorporated into CM in the intestine and remains within CM/CMR during circulation, until the vitamin is incorporated into hepatocytes.Therefore, the transport and storage of vitamin A is largely affected by the nature of the LSEC fenestration. We could label KCs and HSCs within the rat liver separately by utilizing such a characteristic feature of LSECs.View full abstractDownload PDF (1067K) -
Sho Sano, Tasuku Arai, Wataru Kiyono, Rina Watanabe, Taiki Honma, Maya ...2023 Volume 97 Issue 5-6 Pages 275-279
Published: June 25, 2023
Released on J-STAGE: June 30, 2024
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Taiki Homma, Yoshihisa Hirota, Mayu Hayakawa, Yoshitomo Suhara2023 Volume 97 Issue 5-6 Pages 280-283
Published: June 25, 2023
Released on J-STAGE: June 30, 2024
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[in Japanese]2023 Volume 97 Issue 5-6 Pages 284-285
Published: 2023
Released on J-STAGE: June 30, 2024
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[in Japanese], [in Japanese], [in Japanese]2023 Volume 97 Issue 5-6 Pages 285-286
Published: 2023
Released on J-STAGE: June 30, 2024
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[in Japanese]2023 Volume 97 Issue 5-6 Pages 287-288
Published: 2023
Released on J-STAGE: June 30, 2024
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[in Japanese]2023 Volume 97 Issue 5-6 Pages 289-290
Published: 2023
Released on J-STAGE: June 30, 2024
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[in Japanese]2023 Volume 97 Issue 5-6 Pages 290-291
Published: 2023
Released on J-STAGE: June 30, 2024
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2023 Volume 97 Issue 5-6 Pages 291-
Published: 2023
Released on J-STAGE: June 30, 2024
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[in Japanese], [in Japanese], [in Japanese]2023 Volume 97 Issue 5-6 Pages 292-
Published: 2023
Released on J-STAGE: June 30, 2024
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[in Japanese]2023 Volume 97 Issue 5-6 Pages 292-293
Published: 2023
Released on J-STAGE: June 30, 2024
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2023 Volume 97 Issue 5-6 Pages 294-299
Published: 2023
Released on J-STAGE: June 30, 2024
JOURNAL OPEN ACCESSDownload PDF (761K)
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