抄録
Various ethyl dihydroretionates were prepared by the conjugate reduction of β-ionylidenacetaldehydes and C-18 ketones using ethyldimethylsilyl hydride and subsequent Emmons-Horner reaction with C5- or C2-phosphonate. These esters were hydrolyzed to afford the corresponding dihydroretinoic acids and their biological activities were evaluated. Among the synthesized analogs, 8Z-7,10-dihydroretinoic acid showed higher transcriptional activities for the retinoid X receptor responsive element gene and for the RXRα-GAL4 expression gene than 9Z-retinoic acid (a natural ligand).
