2006 年 126 巻 8 号 p. 597-605
Novel fluoroalkylated products where a CF2COOEt group was introduced at the α-position of α,β-unsaturated ketones or the Reformatsky-type products have been obtained selectively by the reaction of BrCF2COOEt and α,β-unsaturated ketones with Et2Zn in the presence of RhCl(PPh3)3 depending on the solvents. Furthermore, the novel α-fluoroalkylated products could synthesize by using various halofluoroalkyl compounds (Rf-X) instead of BrCF2COOEt. On the other hand, this Reformatsky-type reaction by imines gave difluoro-β-lactams or 3-amino-2,2-difluorocalboxylic esters without or with MgSO4•7H2O, selectively.