アスピリンとフェナセチンおよびアセトアミノフェンの併用投与時におけるN, O-Diacetyl-p-aminophenolの生成

抄録

N, O-diacetyl-p-aminophenol (DAPAP) formation after simultaneous administration of aspirin with phenacetin and acetaminophen was investigated in rats and rabbits. 1) When aspirin and acetaminophen were orally administered to rats, DAPAP was detected in the plasma and bile. 2) By the combined use of aspirin with phenacetin, DAPAP was detected in the plasma of rabbits and the bile of rats. 3) DAPAP was observed in the plasma and bile at the earlier stage after dosing. 4) DAPAP was hydrolyzed rapidly in Tris buffer (pH7.0) containing the serum of rats and rabbits.