抄録
The pharmacological effects of water-soluble and insoluble fractions extracted from Zingiber mioga ROSCOE were examined in mice and rats. In mice, Fr-W1, Fr-2 and Fr-W4 in water-soluble fraction significantly prolonged the sleeping time after thiopental Na administration. Intracranial self-stimulation behavior in rats was also depressed by Fr-W1 and Fr-W4. These results suggest the possible existence of some substances that exert central nervous depressive action in these fractions.
