Studies on Anti-inflammatory Agents. III. An Antiinflammatory Constituent of the Genus Acer

Abstract

In the course of the search for anti-inflammatory constituents in the plant origin by using the fertile egg method, some Acer plants (Aceraceae) were found to have the activity. Exploration of Acer crataegifolium SIEB. et ZUCC., an active species, resulted in the isolation of 2, 6-dimethoxy-p-benzoquinone (1) as an active component. This compound (1) administered orally to intact rats at a dose of 50 mg/kg exhibited an inhibitory activity against granulation tissue formation induced by the subcutaneous implantation of cotton pellet.