酸およびアルカリ条件下におけるBetamethasone-17-valerateの挙動

亀谷 哲治; 本多 利雄; 佐藤 秀昭; 鈴木 満; 野尻 澄子

doi:10.1248/yakushi1947.101.9_803

Behavior of Betamethasone-17-valerate in Acidic or Alkaline Medium

TETSUJI KAMETANI, TOSHIO HONDA, HIDEAKI SATO, MITSU SUZUKI, SUMIKO NOJIRI

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Keywords: betamethasone-17-valerate, 9α-fluoro-11β, 17α-dihydroxy-16β-methyl-21-valeroxypregna-1, 4-diene-3, 20-dione, 9α-fluoro-11β, 17α, 21-trihydroxy-16β-methylpregna-1, 4-diene-3, 20-dione, 21-acetoxy-9α-fluoro-11β, 17α-dihydroxypregna-1, 4-diene-3, 20-dione, degradation, rearrangement

JOURNAL FREE ACCESS

1981 Volume 101 Issue 9 Pages 803-805

DOI https://doi.org/10.1248/yakushi1947.101.9_803

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Abstract

Betamethasone-17-valerate (I) was treated with acidic or alkaline solution to investigate its stability in the pharmaceutical preparation. 9α-Fluoro-11β, 17α-dihydroxy-16β-methyl-21-valeroxypregna-1, 4-diene-3, 20-dione (II), a rearrangement product of I, was isolated when I was warmed at 40°C in alkaline medium. Compound II and 9α-fluoro-11β, 17α, 21-trihydroxy-16β-methylpregna-1, 4-diene-3, 20-dione (III), a degradation product of I, were obtained on heating at 100°C. The structure determination of these products was also described.

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