1982 年 102 巻 4 号 p. 381-387
Effects of basic prescription (BASE) in Saiko-prescriptions and five crude drugs contained in BASE on the isolated intestinal smooth muscles of rats were examined. BASE caused a relaxation of the isolated ileum and colon. BASE, Bupleuri Radix and Scutellariae Radix showed anti-acetylcholine and anti-barium ion actions in the isolated colon, but Zizyphi Inermi Fructus did not. The anti-acetylcholine and anti-barium ion activity of Bupleuri Radix increased in the presence of Scutellariae Radix or/and Pinelliae Tuber, indicating that the action of BASE on the colon may be mainly due to that of Bupleuri Radix, Scutellariae Radix and Pinelliae Tuber. In addition, organic solvent extraction of BASE was performed and the n-BuOH extract (Fraction W4) exerted strong anti-acetylcholine and anti-barium ion actions which was more ten times BASE itself.