新規複素環キノン"Benzo[g]pyrido[2,1-b]quinazoline-6,11-dioneおよびBenzo[g]pyrazolo[3,2-b]quinazoline-5,10-diones"の合成
1983 年 103 巻 4 号 p. 473-479
詳細
1983 年 103 巻 4 号 p. 473-479
Ethyl 1, 4-dihydro-1, 4-dioxo-3-methoxy-2-naphthoate (I) is condensed with amidines, 2-aminopyridines and 3-aminopyrazole, to give new tetracyclic quinones (IIIa-c and VI) containing nitrogen atom and hydrogenation of IIIa and IIIb over Pd-C or Raney-Ni afforded 1, 2, 3, 4-tetrahydro (IXa, b) or 1, 2, 3, 4, 7, 8, 9, 10-octahydrobenzo[g]pyrido[2, 1-b]quinazoline (Xa), respectively. Benzo[g]pyrido[2, 1-b]quinazoline derivatives except for Xa showed inhibitory activities to S. aureus and T. interdigitale.
