培養癌細胞の増殖におけるAdenosine Triphosphateの影響

抄録

The effect of exogenous adenosine triphosphate (ATP) on the proliferation of cultured tumor cells has been studied. ATP exerted a cell growth-inhibiting effect at concentrations above 2×10^-4M and 5×10^-6M against Ehrlich tumor cells and L1210 leukemia cells, respectively. At the maximum concentrations of ATP which does not cause the inhibition of the proliferation of both cultured cells, ATP potentiated the growth-inhibiting effect of 5-fluorouracil (FUra), 5-fluoro-2'-deoxyuridine (FdUrd), and 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP). The effect of ATP was much higher with FdUMP than with others in L1210 leukemia cells. These results suggest that ATP may damage tumor cells, at least in part, when FUra and ATP were coadministered intraperitoneally with Ehrlich carcinoma-bearing mice.