YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
皮膚真菌症の実験化学療法的研究(第9報)Maleimide及びSuccinimide系化合物の抗真菌作用
松井 貞良山添 寛渡辺 一幹林 栄一紺屋 一美
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1984 年 104 巻 11 号 p. 1198-1206

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Antifungal activity of eighty-two maleimide and forty-two succinimide compounds against Trichophyton asteroides were examined in vitro. Among these compounds, eleven kinds of N-phenylmaleimides exhibited to have more potent antifungal activity than that of pentachlorophenol as a reference compound. In the N-phenylmaleimides, an increase in the activity was obtained by halogen or alkyl substitutions on the phenyl ring. However, the activity was diminished by halogen or other substitutions at α or α, α'positions on the maleimide ring. The results of therapeutic tests by use of guinea-pigs revealed that a tincture containing 1% N-(2, 6-diethylphenyl) maleimide had 57.7% of cure rate on experimental trichophytosis.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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