生薬修治の化学的解明(第2報)附子(Aconiti Tuber)その1 : 川烏頭(Aconitum carmichaeli DEBX.乾燥根)の含有成分

抄録

In the course of the chemical characterization of crude drug processing, the alkaloidal constituents of Aconiti Tuber ("chuan-wu", imported from Si Chuan, China), the dried tuber of Aconitum carmichaeli DEBX. were investigated. In addition to the known alkaloids such as aconitine (1), hypaconitine (2), mesaconitine (3), talatizamine (5), 14-acetyltalatizamine (6), isotalatizidine (7), karakoline (8), and neoline (9), four new lipo-alkaloids named lipoaconitine (10), lipohypaconitine (11), lipomesaconitine (12), and lipodeoxyaconitine (13), were isolated and their structures elucidated. It was also found that the acetyl functions attached to the C-8 hydroxyls of 1, 2, and 3 were readily interchanged by the fatty acid residues.