芳香族複素環プロモ化物のチオールによる置換反応
1986 年 106 巻 3 号 p. 260-264
詳細
1986 年 106 巻 3 号 p. 260-264
The reaction of 4 (5)-bromo-5 (4)-methylimidazole (1) with methanethiol or benzenethiol in N, N-dimethylformamide in the presence of sodium hydride was found to give not only the corresponding substituted products (2a, b) but also a debromo compound, 4 (5)-methylimidazole (3). By the similar reaction of 3-bromoquinoline (4), 4-bromoisoquinoline (6) and 3-bromopyridine (8) with various kinds of thiol, only the corresponding substituted products (5a-d, 7a-d, 9a, b) were obtained in good yield, respectively, and the formation of debromo compounds such as those described above was not detected.
