Abstract
The safety of the injection therapy has to be secured including that of the injection itself as well as that of the equipment used for injection, i.e. i.v. fluid administration systems. The contamination of insoluble particulate matter ascribed to coating of silicone oil over disposable syringe is being solved by the development of syringe using fluoro-resin laminated rubber. In the case of blood administration set and blood bag system, there are some in which the solvent used for adhesion has been eluted. Further, the relationship between the quality of materials of administration set and the adsorption of drugs has become clear. As regards the plastic container for infusion, insoluble particulate matter and adsorption of drugs have become a problem in connection with the quality of materials used and yet the structure of plastic/rubber combined cap is related to the formation of core, thereby making the improvement. In the case of plastic bag, that made of polyethylene does not adsorb drugs so much and the formation of insoluble particulate matter is a little. For the measures of drug interaction of injection, i.v. fluid administration systems have been applied and the safe and effective method of administration of injection will be established along with the development of I.V. delivery system.
