^<13>C標識体-核磁気共鳴(NMR)トレーサー法の臨床化学への応用.安息香酸の馬尿酸への代謝率の測定

馬場 茂雄; 明楽 一己; 佐久間 千勢子

doi:10.1248/yakushi1947.110.8_586

YAKUGAKU ZASSHI

Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903

Application of ¹³C Label-Nuclear Magnetic Resonance (NMR) Tracer Techniques to Clinical Chemistry. Metabolic Rate of Benzoic Acid to Hippuric Acid

Shigeo BABA, Kazuki AKIRA, Chiseko SAKUMA

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Keywords: NMR, carbon thirteen, tracer, clinical chemistry, metabolic rate, urine, benzoic acid, hippuric acid

JOURNAL FREE ACCESS

1990 Volume 110 Issue 8 Pages 586-590

DOI https://doi.org/10.1248/yakushi1947.110.8_586

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Abstract

A new tracer technique, in which a ¹³C-labeled compound as a biological tracer and ¹³C nuclear magnetic resonance (NMR) as an analytical tool are used, is proposed. In order to verify the applicability of the method to clinical chemistry, [1-¹³C] benzoic acid was administered and [1'-¹³C] hippuric acid excreted in the urine was quantitated by NMR, by using [1-¹³C] hippuric acid as an internal standard.

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