Abstract
In the condensation of 2-amino-5-carbethoxythiazole and acetosulfanilyl chloride, 2-acetosulfanilamido-5-carbethoxythiazole (I), m.p. 194°, is obtained if the reaction proceeds at a low temperature in pyridine, but a saponification product of ethyl carbonate, i.e. sulfacarboxythiazole acetate (II), m.p. 227°, and bis-sulfanilyl compd., are obtained if the reaction proceeds in ace one with the addition of NaHCO3. Alkaline saponification of (I) gives, first, sulfacarboxy hiazole acetate, which is finaly deacetylated to sulfacarboxy-thiazole, m.p. 215°.
