Abstract
Relation between molar ratio and the rate of formation of bis- acetosulfanilyl compound was obtained in the condensation of 2-aminothiazole and acetosulfanilyl chloride in pyridine, acetone and dioxane as solvents. There are two kinds of bis acetosulfanilyl compound, one with m.p. 132° and the other with m.p. 190-240°, the former transiting to the latter when heated in alcohol. Productive experimentations were made with bis-acetosulfanilyl compounds of 2-amino-4-methyl, 2-amino-4, 5-dimethyl-, 2-amino-4-phenyl- and 2-amino-4-phenyl-5-methyl-thiazoles and it was definitely proved that phenyl radical obstructed formation of bis-acetosulfanilyl compound.
