p-アミノメチルフエニルアルキルスルホンの合成

抄録

p-Aminomethylphenyl methyl sulfone was prepared from p-formylamino- or p-phthalimino-methylphenyl sulfochloride which was first reduced to sulfinic acid, treated by methyl iodide in alkaline state to sulfone, and subsequently saponified to remove the formyl or phthalyl group. This method gives the objective compound in a better yield than that starting from p-acetylaminomethylphenyl sulfochloride.
On the other hand, p-aminomethylphenyl alkyl sulfones were prepared from p-methylphenyl alkyl sulfones which were oxidized to p-aldehydephenyl alkyl sulfones, the oximes of which were reduced to obtain the objective compounds.