3,4-Diphenyl-n-hexan系化合体の合成研究 (第1報)

3,4-(m, m´-Dimethyl-p, p´-dipropionyloxydiphenyl)-n-hexanの合成

抄録

Hexene (2)-ol (4), was reacted resp. with anisol and o-cresylmethyl ether with conc. H₂SO₄ as a condensing agent, and 3, 4-(p, p′-dimethoxydiphenyl)-n-hexane and 3, 4-(m, m′-dimethyl-p, p′-dimethoxydiphenyl)-n-hexane, respectively, were obtained.
The structures of these compounds were proved by the direct comparison with the standard products obtained by other synthetic method, and also from analytical values. Demethylation of 3, 4-(m, m′-dimethyl-p, p′-dimethoxydiphenyl)-n-hexane gave 3, 4-(m, m′-dimethyl-p, p′-dihydroxydiphenyl)-n-hexane from which dipropionate and dibenzoate of the subject compound were obtained. The comparison of the synthesized 3, 4-(m, m′-dimethyl-p, p′-dihydroxydiphenyl)-n-hexane with the data in literature showed a difference of 21-22° in the melting point. Reason for this difference is at present unknown. The synthetic compounds obtained in the present experiment will be put to animal test as to the presence of sexual excitation.