Abstract
Hydrogenation of 2-methyl-4-amino-5-cyanopyrimidine with nickel catalyst results in the formation of a primary amine, 2-methyl-4-amino-5-aminomethylpyrimidine, with a by-product, not of a secondary amine, but of c, c′-di-(2-methyl-4-aminopyrimidyl)-methylalmethylimide-(5), (I), a compound not reduced as yet, which possesses a strong resistance against reduction, especially in alcoholic solvent than in water and it can be reduced to a secondary amine by itself. (I) can be synthesized from 2-methyl-4-aminopyrimidyl-aldehyde-(5), (II), and 2-methyl-4-amino-5-aminomethylpyrimidine, or vice versa. (II) can be reduced to 2-methyl-4-amino-5-hydroxymethylpyrimidine catalytically with Ni or Pd-coal, or by Al-amalgam method.
