Abstract
Several kinds of 1, 1-dimethyl-4-acyl-cyclohexane dione-3, 5 were synthesized as tricarbonylmethane type compounds, in which the acyl radicals were the cinnamoyl, furfurylidene-acetyl, 4, 5-methylene-dioxy-cinnamoyl, 4-hydroxy-5-methoxycinnamoyl, 4, 5-dimethoxy-6-carboxycinnamoyl and cinnamoyl-ideneacetyl radicals and those of dehydracetic acid, 3-acetyl-4-hydroxycoumarine and 3-benzoyl-4-hydroxycoumarine. Antibacterial actions of these compounds against Staphylococcus aureus Terashima and avian type Mycobacterium tuberculosis in vitro were tested and it was found that the antibacterial action increased when one of the 3 carbonyl radicals in the compound was conjugated to a double bond and when this conjugated system increased. However, of the compounds synthesized, the antibacterial action was found to be lower in 1, 1-dimethyl-4-acyl-cyclohexane dione-3, 5 in which the acyl radical contained a furan nucleus instead of benzene and in those with benzenue nucleus possessing several substituents compared with that without the substituents.
