脂肪属アニールとグアニジン又はその誘導体との縮合によるピリミジン類の新製法
1951 年 71 巻 2 号 p. 80-81
詳細
1951 年 71 巻 2 号 p. 80-81
Formylacetone-anil and guanidine were boiled in alcohol on a water bath for one hour in the presence of sodium ethoxide, and 2-amino-4-methylpyrimidine was obtained in a 70% yield. Sulfamerazine was synthesized by the same method in a 15% yield using sulfaguanidine. Sulfamerazine is also obtained by fusing formylacetone-anil and sulfaguanidine in the presence of NaOH in a yield of 60%. 2-Aminopyrimidine was obtained by boiling for 4hrs. malonedialdehyde-dianil and guanidine in alcohol in the presence of sodium ethoxide, in a yield of about 30%. In this reaction, sulfadiazine was not obtained by the use of sulfaguanidine.
