1951 年 71 巻 2 号 p. 80-81
Formylacetone-anil and guanidine were boiled in alcohol on a water bath for one hour in the presence of sodium ethoxide, and 2-amino-4-methylpyrimidine was obtained in a 70% yield. Sulfamerazine was synthesized by the same method in a 15% yield using sulfaguanidine. Sulfamerazine is also obtained by fusing formylacetone-anil and sulfaguanidine in the presence of NaOH in a yield of 60%. 2-Aminopyrimidine was obtained by boiling for 4hrs. malonedialdehyde-dianil and guanidine in alcohol in the presence of sodium ethoxide, in a yield of about 30%. In this reaction, sulfadiazine was not obtained by the use of sulfaguanidine.