駆虫薬の研究 (第7報)
α-〔2-Hydroxy-3-ketocyclohexyl〕-propionic Acid Lactoneの合成研究
1952 年 72 巻 11 号 p. 1451-1455
詳細
1952 年 72 巻 11 号 p. 1451-1455
Attempts to obtain the lactone of α-(2-hydroxy-3-ketocyclohexyl)-propionic acid (II) by the hydration of the double bond of diethyl (3-ketocyclohexen-(1)-yl)-methylmalonate (I) were unsuccessful and, therefore, the double bond in (I) was hydroxylated in aqueous solution of potassium permanganate, saponif ied, and heated in acetic anhydride, by which the following three unsaturated lactones, closely analogous to (II), were obtained: Lactones of α-(2-hydroxy-3-acetoxycyclohexen-(2)-ylidene)-propionic acid (XII), of α-(2-hydroxy-3-acetoxycyclohexadien-(1, 3)-yl)-propionic acid (XIII), and of α-(2-hydroxycyclohexen-(1)-yl)-propionic acid (XIV). Other allied compounds are also described.
