鎭痙剤の研究 (第1報)
γ-ヂフェニルアルカノールアミン類の合成
1952 年 72 巻 12 号 p. 1592-1594
詳細
1952 年 72 巻 12 号 p. 1592-1594
Five kinds of diphenylbutanolamines and two kinds of diphenylpropanolamines were prepared to examine their antispasmodic actions. The butanolamines are all new compounds and were prepared by the Grignard reaction of β-aminobutyric esters. The anticholinergic activity of these compounds was found to be the strongest in 1, 1-diphenyl-3-piperidylbutanol, being one-third to one-half of the action of atropine sulfate when tested with excised small intestines of guinea pigs.
