YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
女性ホルモン様物質の合成研究 (第2報)
β-Anisyl-α,β-dialkylpropionic acidの合成について
吉田 茂赤木 三郎
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1952 年 72 巻 3 号 p. 319-321

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In order to be used for the synthesis of benzesterol, β-anisyl-α-ethylvaleric acid was prepared as follows: Condensation of anisaldehyde and ethyl malonate yielded ethyl anisalmalonate to which was applied ethylmagnesium iodide to effect 1, 4-addition to obtain ethyl α-anisylpropylmalonate, followed by the application of sodium and ethyl iodide to yield ethyl α-anisylpropylethylmalonate. The hydrolysis and decarboxylation of the latter yielded the objective compound.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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