抄録
Combined effect of Oxine with iron, zinc, magnesium, or copper sulfate was tested with Tricophyton and Achorion in the range of pH 5-9. Addition of iron and zinc salts was found to cancel the effect, that of magnesium, to decrease the effect, while the addition of copper was found to be about equal or in some instances increase the effect. The course of such a behavior was assumed to be due to the fact that iron and zinc bond completely with Oxine in pH 5-9 range thereby nullifying its effect while such an effect was assumed to remain in the case of magnesium due to incomplete salt formation. However, copper is known to undergo complete bonding in this pH range and this is somewhat inconsistent. The copper salt of Oxine was found to substitute with iron from which it may be assumed that the copper salt acts in the same way as Oxine itself. It was also found that the copper salts of isonictonic acid hydrazide, p-aminosalicylic acid, and hinokitiol, which are effective as the free compounds, also undergo substitution with iron. These experimental results support the theory of Zentmeyer regarding Oxine and confirmed that the inconsistent results of Sexton was due to the use of a specific material such as the copper salt.
