1954 年 74 巻 5 号 p. 463-466
Titrations of antipyrine, aminopyrine, sulpyrine, antipyrine salicylate, migrenin, and pyrabital in glacial acetic acid with 0.1N perchloric acid were carried out. With the exception of sulpyrine, the determinations were found possible with an accuracy of 0.05-0.2%. Antipyrine was titrated one mole as one equivalent. Aminopyrine was titrated first one mole as one equivalent but could not be determined at the next neutralization point. Sulpyrine was titrated first one mole as two equivalents and the next neutralization point was obscure. The basicity of aminopyrine is stronger than that of antipyrine or sulpyrine. Antipyrine salicylate was titrated as in the case of antipyrine alone since salicylic acid does not show its acidity in the glacial acetic acid, as is the case with citric acid and barbital. Migrenin can be titrated at the same neutralization point as the mixture of antipyrine and caffeine it contains, as long as their ratio is known. Pyrabital can also be titrated as its componental aminopyrine and the determination values become varied when the mixture ratio of componental aminopyrine and barbital is varied. The titration was possible when glass-calomel electrodes were used but the use of an indicator sometimes necessitated the use of color comparators.