INAHの体内変化に関する研究 (第2報)

INAH投与による尿中成分の変化

抄録

Oral administration of 2.0-6.5mg./kg. of INAH resulted in the increase of the amount in urine of acid and alkaline reductive substances, conjugated glucuronide, and N¹-methylated INAH derivative. On the other hand, there was a decrease of ethereal sulfate. From these facts, the formation of isonicotinic acid glucuronide and N¹-methylated derivative as the biologically changed products of INAH was assumed.