Aminohydantoin誘導体並びにその関連化合物に関する研究 (第2報)

1-Amino-2-thiohydantoinに就いて

抄録

Ethyl hydrazinoacetate hydrochloride (II) and potassium thiocyanate (III) were fused together to form ethyl N¹-thiocarbamylhydrazinoacetate (IV), m.p. 130°, which was cyclized by treatment with dilute mineral acid. Rendering this solution slightly acid by the addition of alkali yielded 1-amino-2-thiohydantoin (VI), which was also formed by the heating of (II) and (III) at a high temperature for a long period, as pale yellow needle crystals, m.p. 188° (decomp.). Hydrochloride of (VI), colorless rhombic crystals, m.p. 168° (decomp.). These compounds were derived through the benzylidene compounds to the known compounds by desulfurization and their structures confirmed.