Solubilizationの製剤学への応用 (第4報)

Vitamin A PalmitateのSolubilization

抄録

Solubility of vitamin A palmitate in the aqueous solution of various surface active agents of polyhydroxyethylene series was examined. It was found that a different rate of solubility occurred when the sample was added to the aqueous solution of surfactants and the mixture shaken and when the sample and surfactant was mixed and diluted with water. According to the second method of testing, the solubility of vitamin A palmitate increases, the larger the lypophylic radical and smaller the hydrophilic radical of the surfactants.