含窒素環化合物の合成 (第99報)
ヒノリン誘導体について その1
1955 年 75 巻 11 号 p. 1434-1436
詳細
1955 年 75 巻 11 号 p. 1434-1436
2-Methoxy (or ethoxy)-6-nitrobenzamide was derived to 2-methoxy (or ethoxy)-6-nitrobenzoic acid by the application of sodium nitrite and sulfuric acid. Reaction of 2-methoxy-6-aminobenzoic acid and nitroacetaldoxime, in hydrochloric acid solution, afforded 2-methoxy-6-(β-nitroethylidene) aminobenzoic acid, whose cyclization gave 3-nitro-4-hydroxy-5-methoxyquinoline. Decomposition of 2-cyanoquinolines in acetone, by the Radziszewsky method, afforded the corresponding acid amides in a good yield.
