巻号一覧
75 巻, 11 号
選択された号の論文の42件中1～42を表示しています
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紫外線吸収スペクトルによるピリジン塩基の定量津田 恭介, 丸山 正生, 池川 信夫1955 年 75 巻 11 号 p. 1309-1313
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーThe picoline, lutidine, and collidine fractions from the coal tar bases were quantitatively determined by the ultraviolet absorption spectra and qualitatively estimated by the infrared absorption spectra. Determination of a mixture (β-picoline fraction) of β- and γ-picolines and 2, 6-lutidine, and a mixture (2, 4-lutidine fraction) of 2, 4-, 2, 5-, and 2, 3-lutidines gave satisfactory results but that of a mixture (sym-collidine fraction) of 2, 4, 6- and 2, 3, 5-collidine and 3, 5-lutidine was somewhat inaccurate.抄録全体を表示PDF形式でダウンロード (538K) -
駆虫成分カイニン酸関連化合物について その1宮崎 道治, 渡邊 久禮, 水野 長太郎, 高野 忠義, 森本 明1955 年 75 巻 11 号 p. 1314-1317
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーHydrolysis of the pale yellow crystals (I), m.p. 140°, C16H18O2N2, obtained at the time of the pyrolysis of kainic acid, afforded a monocarboxylic acid of a pyrrole compound as colorless needles, m.p. 175° (decomp.), C8H11O2N. This substance agrees with one (m.p. 175° (decomp.)) of the two α-monocarboxylic acids obtained by the Grignard reaction of 3-isopropylpyrrole formed by the soda-lime dry-distillation of kainic acid. It also agrees with 2-carboxy-4-isopropylpyrrole (II), m.p. 180° (decomp.), C8H11O2N, obtained by the decarboxylation, under various conditions, of 2-carboxy-3-ethoxycarbonyl-4-isopropylpyrrole (III). It has now been clarified that (II) is obtained during the alkali fusion of kainic and dihydrokainic acids, and that (I) is the pyrrocol compound of (II), i.e. 4, 4′-diisopropylpyrrocol. At the same time, 2, 3-dicarboxy-4-isopropylpyrrole, m.p. 200° (decomp.), and 3-carboxy-4-isopropylpyrrole, m.p. 121° (decomp.), were derived from (III), showing that the crystals of m.p. 132° (decomp.), obtained as the α-carboxylic acid of 3-isopropylpyrrole, is 2-carboxy-3-isopropylpyrrole.抄録全体を表示PDF形式でダウンロード (598K) -
β-アミノエタノール及びβ-アルキルアミノエタノールよりピペラジン類の合成石黒 武雄, 北村 英一, 松村 正毅, 小川 弘1955 年 75 巻 11 号 p. 1318-1321
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーHeating of β-aminoethanol as a hydrochloride or hydrobromide for 1.5-3.5hours at 240-250° results in the formation of piperazine in 44-51% yield of the theoretical amount and a small amount of β, β′-diaminodiethyl ether (2-5% of the theoretical yield) is formed as a by-product. Heating of β-methylaminoethanol hydrochloride under the same conditions affords N-methylpiperazine (yield, 26%), N, N′-dimethylpiperazine (yield, 5%), and N, N′-dimethylethylenediamine (yield, 12%). The same reaction of β-dimethylaminoethanol gives only N, N′-dimethylpiperazine (yield, 26%). In the case of β-aminoethanol and mono-, di-, or trialkylamine hydrochloride gives, according to reaction conditions, N-alkyl- or N-dialkylethylenediamine and N-alkylpiperazine. In the case of β-aminoethanol and aromatic amines, only N-arylethyl enediamine is formed and N-arylpiperazine is not obtained. Catalytic vapor phase reactions of the above substances were not successful.抄録全体を表示PDF形式でダウンロード (721K) -
中川 俊夫, 森 芳夫1955 年 75 巻 11 号 p. 1322-1325
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーWater-soluble vitamin E derivative was obtained by the reaction of α-tocopheryl dichlorophosphate and polyethylene glycol. The reaction product was purified through alumina chromatography and from the phosphorus content, ultraviolet and infrared absorption, average molecular weight, and the hydrolyzates, the product was assumed to be a mixed phosphate of α-tocopherol and polyethyleneglycol.抄録全体を表示PDF形式でダウンロード (570K) -
Oxycellulose法により得られる有効成分について その1大塚 英夫1955 年 75 巻 11 号 p. 1325-1328
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーACTH, obtained from bovine anterior pituitary by the oxycellulose method, was examined by paper electrophoresis and this revealed that it was composed of at least two components. The amino acid component contained, besides the usual amino acids, an unknown substance which colors with Amidoschwarz 10B. As the terminal group phenylalanine, threonine, tyrosine, and the foregoing unknown substance were observed.抄録全体を表示PDF形式でダウンロード (663K) -
Oxycellulose法により得られる有効成分について その2大塚 英夫1955 年 75 巻 11 号 p. 1328-1331
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーThe ACTH obtained from bovine anterior pituitary was purified by column chromatography using oxycellulose. By elution with hydrochloric or acetic acid, the effluent was divided into 3-4 fractions. The initial effluent lacked the ACTHaction and colored violet with Amidoschwarz 10B. The next effluent had the strongest hormone activity and is an ACTH-active peptide.抄録全体を表示PDF形式でダウンロード (472K) -
その単離及び精製秋谷 七郎, 中澤 泰男1955 年 75 巻 11 号 p. 1332-1334
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーA new glycolipide, structurally different from the known types of cerebrosides, was extracted from the soft tissues of an oyster and was purified by chromatography.抄録全体を表示PDF形式でダウンロード (487K) -
構成糖について秋谷 七郎, 中澤 泰男1955 年 75 巻 11 号 p. 1335-1337
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーThe sugar portion of the new glycolipide obtained from oyster was examined and its structure was assumed to be D-glucopyranose 4↔1 D-glucopyranose 4↔1 L-fucopyranose, a trisaccharide composed of 2 moles of D-glucose and 1 mole of L-fucose.抄録全体を表示PDF形式でダウンロード (450K) -
メゾオキザル酸及び関連化合物の微量定性定量落合 英二, 岡本 敏彦, 上田 亨1955 年 75 巻 11 号 p. 1338-1341
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーAs a preliminary to following biological change of mesoxalic acid, possessing glycopenic action, microdetection and microdetermination of mesoxalic acid were examined. For the microdetection, paper partition chromatography was employed. Mesoxalic acid was derived to its p-nitrophenylhydrazone, submitted to paper chromatography, the isolated spot was cut out, eluted, and the solution basified with sodium hydroxide was submitted to colorimetry. Tartronic acid formed by the reduction of mesoxalic acid was found to form molybdenum blue with phosphomolybdic acid solution and this was utilized for colorimetry.抄録全体を表示PDF形式でダウンロード (604K) -
大熊 誠一1955 年 75 巻 11 号 p. 1342-1345
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーMicrodetection of aromatic and heterocyclic nitro compounds by sodium pentacyanoammineferroate was examined and some presumptions were made as to their coloration mechanism抄録全体を表示PDF形式でダウンロード (545K) -
石黒 武雄, 古座谷 醇1955 年 75 巻 11 号 p. 1346-1349
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリー1) Electric conductivity of a solution of diphenylhydantoin sodium, while heating above the saturation temperature and cooling below saturation temperature, was measured. The specific electric conductivity-temperature curve suddenly breaks at a point where the crystals completely dissolve or where crystals begin to precipitate out. The electric conductivity curve shows a hysteresis loop at the time of rise or fall of the temperature.
2) When the solution of diphenylhydantoin sodium is cooled to supersaturation below the saturation temperature, the logK-1/T curves are represented by two straight lines crossing each other at the saturation temperature, and the slope of the straight line on the supercooled solution side is usually greater than that of the solution line.
3) The foregoing results have shown that it is possible to know the solubility of diphenylhydantoin sodium by the measurement of the electric conductivity of its solution.抄録全体を表示PDF形式でダウンロード (798K) -
富田 眞雄, 久郷 威彦1955 年 75 巻 11 号 p. 1350-1354
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリー3, 4-Diethoxydiphenyl ether-6, 4′-dicarboxylic acid (XVIII), m.p. 245-247°, and its dimethyl ester (XIX), m.p. 106-108°, were synthesized in order to compare with substances corresponding to the diethoxydiphenyl ether-dicarboxylic acid, m.p. 265-267°, obtained by the oxidation of magnolamine tetraethyl ether, and its dimethyl ester, m.p. 112-113°. The melting points of the synthetic products were found to be similar to but lower than those of the products obtained by the oxidation of the natural substance. In order to obtain the corresponding diethoxy compound (XVIII) from 3, 4-dimethoxydiphenyl ether-6, 4′-dicarboxylic acid (II) by the demethylation of the latter with hydrobromic acid followed by ethylation, an attempt was made on the demethylation with hydrobromic acid and acetic acid by which 3, 4-dihydroxydiphenyl ether-4′-carboxylic acid (VI), in which the carboxyl group in the 6-position of (II) had liberated as carbon dioxide, was obtained, instead of the objective 3, 4-dihydroxydiphenyl ether-6, 4′-dicarboxylic acid (III).抄録全体を表示PDF形式でダウンロード (850K) -
富田 眞雄, 久郷 威彦1955 年 75 巻 11 号 p. 1354-1357
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリー2, 3-Diethoxydiphenyl ether-5, 4′-dicarboxylic acid (VIII), m.p. 229-230°, and its dimethyl ester (VII), m.p. 72-73°, were prepared. The starting material for such synthesis, 3, 4-dimethoxy-6-bromobenzoic acid (III) or the corresponding diethoxy compound, when treated with hydrogen bromide and glacial acetic acid, undergoes dealkylation to form 3, 4-dihydroxy-6-bromobenzoic acid, as well as the transition of the bromine from 6- to 5-position and to form 3, 4-dihydroxy-5-bromobenzoic acid (IV).抄録全体を表示PDF形式でダウンロード (772K) -
Paper ChromatographyによるTetracycline群およびVitamin B12の定性的分離三宅 彰, 樹下 友治1955 年 75 巻 11 号 p. 1358-1361
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーA paper chromatographic technique whereby the compounds of the tetracycline series separated from each other or from vitamin B12 was devised by impregnating various kinds of filter paper with Theorell buffer of varying pH and developing with the upper layer of a freshly prepared mixture of butanol, acetic acid, and water (4:1:5). In order to obtain a definite Rf values, the filter paper chosen must show no fluorescence, no absorption, and small adsorption. The Theorell buffer is adjusted to pH 3.5-6.2 and in order to impregnate a definite amount of the solution in the filter paper, the value of (aS-aW)/aW was fixed at 3.0-4.0. The objective was attained by developing with the above solvent mixture by the the one-dimensional ascending method.抄録全体を表示PDF形式でダウンロード (937K) -
Anhydrotetracycline体の生成と生物学的性質立岡 末雄, 緒方 浩一, 森本 皎, 樹下 友治1955 年 75 巻 11 号 p. 1362-1366
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーIt has been found that the heating of chlorotetracycline or tetracycline in dilute hydrochloric acid resulted in the facile formation of the corresponding anhydrotetracycline compounds. These substances had already been prepared by Waller and others and by Conover and others from the tetracycline compounds under drastic conditions such as by treatment with hydrogen iodide or with methanolic hydrochloric acid and their structures have already been elucidated. However, since no report has been made on their biological actions, this point was examined.
1) Antibacterial spectrum: Both showed approximately the same antibacterial action against the gram-positive and gram-negative bacteria. Antibacterial action against avian type tubercle bacilli was apparent but extremely small against human type bacilli.
2) Relationship between pH and antibacterial spectrum: High antibacterial power was shown in an acid medium.
3) Resistance of antibiotic-producing Actinomyces against these substances: Actinomyces which produce chlorotetracycline, oxytetracycline, chloramphenicol, dextromycin, actinomycin, and streptothricin do not show any resistance to the present substances.
These results suggest that the aromatization of the C-ring in the molecules of the tetracycline series compounds does not result in the loss of the antibacterial action and that such action mechanism is different from that of chlorotetracycline or oxytetracyline.抄録全体を表示PDF形式でダウンロード (784K) -
トリエタノールアミンよりピペラジン類の合成石黒 武雄, 北村 英一, 松村 正毅, 小川 弘1955 年 75 巻 11 号 p. 1367-1369
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーHeating of triethanolamine hydrochloride at 200° for three hours afforded β-4-morpholinoethanol in 50% yield but the difference in the reaction temperature and duration results in the formation of morpholine, 1, 2-dimorpholinoethane, 2, 2′-dimorpholinediethyl ether, and piperazine. Heating of triethanolamine with the hydrochloride of mono-, di-, or trialkylamine at 250° invariably affords N-alkylpiperazine in approximately 30% yield, with about 15% of morpholine as a by-product. Vapor phase reaction of ethylene glycol and ammonia, with silica-alumina catalyst, failed to form piperazine and morpholine, and only a small amount of α- and γ-picoline were detected.抄録全体を表示PDF形式でダウンロード (532K) -
接触気相反応による1,4-diazabicyclo 〔2,2,2〕 octaneの合成石黒 武雄, 北村 英一, 松村 正毅, 小川 弘1955 年 75 巻 11 号 p. 1370-1373
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリー1, 4-Diazabicyclo [2, 2, 2] octane (triethylenediamine) was prepared by catalytic vapor phase reaction with silica-alumina coprecipitate as the catalyst. The reaction temperature was 275-350°, either at ordinary or reduced pressure. The yield was 4% from monoethanolamine, 6% from diethanolamine, 21% from N-(β-hydroxyethyl)-piperazine, and 32% from N, N′-di (β-hydroxyethyl) piperazine. In this reaction, the formation of piperazine was totally nil or if formed, only in a minute amount.抄録全体を表示PDF形式でダウンロード (733K) -
Resorcinol及びそのモノメチルエーテルに対するBenzenediazonium Chloride及びo-Toluenediazonium Chlorideの反応金庭 延慶1955 年 75 巻 11 号 p. 1373-1376
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーBy coupling 1 mole of diazonium salt of aniline, o-toluidine, or p-nitroaniline to 1 mole of resorcinol monomethyl ether, compounds in which the coupling occured in the para-position of the hydroxyl and the ortho-position of the methoxyl were obtained as the chief reaction products. The use of 2 moles of the diazonium salts afforded bisazoresorcinol monomethyl ether, m.p. 176° (acetate, m.p. 167°), in the case of aniline, and of m.p. 170° (acetate, m.p. 141°) in the case of o-toluidine. The position of the azo group in these compounds must be 4, 6-position since the application of 1 mole of the diazonium salt to 4-azoresoicinol 1-methyl ether and 4-azoresorcinol 3-methyl ether always gives identical compound. When two moles of diazonium salt is coupled to resorcinol, the product is either 2, 4- or 4, 6- bisazoresorcinol according to whether the medium is mild or caustic alkali. In the case of resorcinol monomethyl ether, there was no difference in the site of coupling of the azo group with the change in the medium.抄録全体を表示PDF形式でダウンロード (721K) -
カンファン誘導体について高橋 酉藏, 堀 幹夫, 鈴木 安司1955 年 75 巻 11 号 p. 1377-1379
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーBy the application of α-haloacyl halides to 5-aminocamphor or d-borneol, 3-α-haloacylaminocamphors and d-bornyl α-haloacylates were prepared. Condensation of these haloacyl derivatives with dimethyl- or diethylamine afforded the coresponding 3-α-dialkylaminoacylaminocamphors and d-bornyl α-dialkylaminoacylates. By the application of β-diethylaminoethyl chloride to 3-aminocamphor, 3-β-diethyaminoethylaminocamphor was prepared and by the condensation of β-diethylaminoethyl and β-dimethylaminoethyl chlorides to the sodium salt of d-borneol, the corresponding β-dialkylaminoethyl d-bornyl ethers were obtained.抄録全体を表示PDF形式でダウンロード (514K) -
アミノチクロヘキサン誘導体について その4高橋 酉藏, 堀 幹夫, 鶴羽 肇1955 年 75 巻 11 号 p. 1380-1382
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリー1) Application of benzoyl, p-chlorobenzoyl, or m-bromobenzoyl chloride to 1-ethyl-, 1-phenyl-, and 1-p-chlorophenyl-2-dimethylaminomethylcyclohexanol, afforded the corresponding benzoates. Treatment of 1-ethyl- and 1-phenyl-2-dimethylamino-methylcyclohexanol with thionyl chloride afforded 1-chloro derivatives.
2) Grignard reagents were prepared from o-chlorobromobenzene, p-methyl-m-chloroiodobenzene, p-chloroiodobenzene, m-dibromobenzene, and p-dibromobenzene, these were respectively reacted with 2-dimethylaminomethylcyclohexanone, and the corresponding 1-halophenyl-2-dimethylaminomethylcyclohexanols were prepared.
3) m-Nitrobenzoate obtained by the condensation of 1-ethyl-2-dimethylamino-methylcyclohexanol and m-nitrobenzoyl chloride was reduced to the amino derivative and condensed with ethyl chlorocarbonate to obtain m-ethoxycarbonylamino derivative.抄録全体を表示PDF形式でダウンロード (555K) -
trans-π-オキソカンファーの定量山岸 正治, 横尾 亮, 井上 三郎1955 年 75 巻 11 号 p. 1383-1384
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーDetermination of trans-π-oxocamphor was established by reacting trans-π-oxocamphorwith 2, 4-dinitrophenylhydrazine, removing the hydrazone thereby formed, and measuring the amount of 2, 4-dinitrophenylhydazine before and after the reaction by azotometry.抄録全体を表示PDF形式でダウンロード (278K) -
アゾトメトリーにおけるネスレル試薬の利用山岸 正治, 横尾 亮, 井上 三郎1955 年 75 巻 11 号 p. 1384-1386
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリー1) Determination of aldehydes was successfully established by reacting aldehydes with an excess of the Nessler reagent and determining the excess amount of Nessler reagent by azotometry.
2) Aromatic hydroxyaldehydes cannot be determined by this method.抄録全体を表示PDF形式でダウンロード (468K) -
Riboflavinの定量山岸 正治, 横尾 亮, 井上 三郎1955 年 75 巻 11 号 p. 1386-1389
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーDetermination of riboflavin was effected by the hydrolysis of riboflavin in 1-2% sodium hydroxide solution and determining the amount of urea formed by sodium hypobromite azotometry.抄録全体を表示PDF形式でダウンロード (532K) -
N-置換-Thiazolidine-2-thione誘導体に対するハロゲンアルキルの作用について吉田 茂, 淺井 素次1955 年 75 巻 11 号 p. 1389-1391
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーApplication of alkyl iodide to 3-(2-methyl-4-amino-5-pyrimidylmethyl)-3a-methyltetrahydrofuro [2, 3-d] thiazoline-2-thione (III) and 4-hydroxy-4-methyl-5 β-hydroxyethylthiazolidine-2-thione, and its acyl derivative (IV) affords, according to the amount of the alkyl iodide used and reaction conditions, mono or dihydriodide of thiochromine (II). It was shown in the present series of experiments that (II) is formed from (III) and (IV), respectively through the intermediates (V) and (VI).抄録全体を表示PDF形式でダウンロード (489K) -
N-置換チアゾリジン-2-チオン誘導体の研究石塚 亘1955 年 75 巻 11 号 p. 1392-1395
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーN-Benzyl-4-methyl-4-hydroxy-5-benzylidenethiazolidine-2-thione (IV), obtained by the condensation of benzylamine, carbon disulfide, and α-bromobenzalacetone, formed N-benzyl-4-methylene-5-benzylidenethiazolidine-2-thione (V) by hydration and undergoes addition reaction with maleic acid to give a malefic acid adduct (VI). On the other hand, 4-benzyl-4-methyl-5-vinylthiazoline-2-thione (VIII) and 3-(2-methyl-4-amino-5-pyrimidylmethyl)-4-methyl-5-vinylthiazoline 2-thione (VIII′) do not form such an adduct. N-Benzyl-4-hydroxy-4-methyl-5-benzylidenethiazolidine-2-thione (IX) gives a benzoyl ester (X).抄録全体を表示PDF形式でダウンロード (539K) -
田村 三郎, 谷 晃1955 年 75 巻 11 号 p. 1396-1399
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリー1) Potency determination of synthetic curare-active substances was successfully made by the preparation of a blood-perfusion sample of rat diaphragm. Comparison of this method with the existing head-drop and Claude-Bernard methods was made with 8 kinds of polymethylene-bis (3-methyl-6, 7-methylenedioxy-Py-tetrahydroiso quinoline) methiodide and somewhat parallel results were obtained.
2) Of the samples used, the decamethonium compound showed the strongest activity and the relationship between the number of the methylene group and the curare-like action was approximately equal to the rules heretofore reported.
3) There was found no significant relationship between the curare-like action and toxicity.
4) The action of this decamethonium compound is antagonized by neostigmine.抄録全体を表示PDF形式でダウンロード (739K) -
配糖体A及び配糖体Bについて その1富永 敏夫1955 年 75 巻 11 号 p. 1399-1404
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーThe analytical values of the glycoside A agree with that of a mixture of kaempferol monorhamnoside and 3, 5, 7, 4′-tetrahydroxyflavanone monorhamnoside but the separation of these two substances by various solvents proved difficult. Methylation of glycoside A with diazomethane under mild conditions and hydrolysis of the product afforded 3, 5-dihydroxy-7, 4′-dimethoxyflavone (III) as yellow needles, m.p. 179-180° and 3, 5-dihydroxy-7, 4′-dimethoxyflavanone (IV) as colorless needles, m.p. 189-190°. when a large excess of diazomethane was applied, hydrolysis of the product afforded 3-hydroxy-5, 7, 4′-trimethoxyflavone (V) as pale yellow needles, m.p. 145-146°, and 3-hydroxy-5, 7, 4′-trimethoxyflavanone (VI) as amorphous substance of m.p. 60° (indistinct). Therefore, the glycoside A is assumed to be a mixed cystals of kaempferol 3-L-rhamnoside (VII) and 3, 5, 7, 4′-tetrahydroxyflavanone 3-L-rhamnoside (VIII). (VIII) can be isolated by adsorption of (VII) on carbon from 70% ethanolic solution of the glycoside A.
The hydrolysis of glycoside B (IX), C21H22O10, afforded L-rhamnose and rac.-3, 5, 7, 4′-terahydroxyflavanone, m.p. 231-232°. Application of an excess of diazomethane followed by hydrolysis results in the formation of 3-hydroxy-5, 7, 4′-trimethoxyflavanone as an amorphous substance of m.p. 60° (indistinct). Therefore, (IX), as (VIII), is assumed to be 3, 5, 7, 4′-tetrahydroxyflavanone 3-L-rhamnoside.
Both (VIII) and (IX) give reactions common to flavonoids and their ultraviolet absorption spectra suggest them to be flavanonol compounds (Fig. 1) They are probably stereoisomers. Both are new substances and were named engelitin (VIII) and isoengelitin (IX).抄録全体を表示PDF形式でダウンロード (998K) -
ヒノリン系化合物の一新合成法 その1小澤 樹夫, 長岡 達1955 年 75 巻 11 号 p. 1405-1407
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーα-Aceto-γ-butyrolactone reacts easily with aniline in ethanol to form phenylimino-acetobutyrolactone. When this is heated with phosphoryl chloride in a sealed tube, the lactone ring is cleaved to chloroethyl and carboxyl, the latter undergoes dehydration in the ortho-position of aniline to form 4-oxoquinoline. This is immediately enolized and chlorinated to form 3-chloroethyl-4-chloroquinaldine (II), which is derived to 3-vinylquinaldine (IV) and 3-ethylquinaldine (V).抄録全体を表示PDF形式でダウンロード (577K) -
ヒノリン系化合物の一新合成法 その2小澤 樹夫, 長岡 達, 光野 京子, 築山 祀子1955 年 75 巻 11 号 p. 1407-1410
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーCondensation characteristics of acetobutyrolactone were examined with 16 kinds of aromatic amines and it was found that p-nitroaniline alone failed to undergo condensation. Use of aniline analogs possessing methyl, methoxyl, hyroxyl, or halogen substituents afford phenylimino-acetobutyrolactone and makes it possible to prepare 3-chloroethyl-4-chloroquinaldines with such substituents in 5-, 6-, 7-, or 8-positions.抄録全体を表示PDF形式でダウンロード (757K) -
ピリジン-水-苛性ソーダ系の相互溶解度石黒 武雄, 河口 太郎, 松本 克1955 年 75 巻 11 号 p. 1410-1413
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーMutual solubility of pyridine-water-sodium hydroxide system was measured at 0, 30, 60, and 90°, and their equilibrium diagrams and conjugation curves were obtained. Mutual solubility of pyridine and water is markedly affected by temperature and the presence of caustic alkali. At a definite temperature, the mutual solubility decreases with an increase in the concentration of sodium hydroxide, while the concentration of pyridine in equilibrium with a definite concentration of sodium hydroxide solution increases with the increase of temperature.抄録全体を表示PDF形式でダウンロード (569K) -
トリエチレングリコール-水系の蒸気圧及び水活量石黒 武雄, 松本 克1955 年 75 巻 11 号 p. 1414-1417
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーVapor pressure of the triethylene glycol-water system in temperature ranges of 30-70° was determined and empirical formula was proposed from the vapor pressure curve and logp-1/T curve. The water activity and vapor density were calculated from the vapor pressure of the aqueous solution and using aqueous triethylene glycol solution, it was made possible to seek conditions required to maintain the atmospheric moisture at a definite rate from a graph. The vapor pressure of triethylene glycol was determined in the temperature range of 15-30° with a pendulum tensimeter and the following empirical formula was obtained.
logp=8.9933-3534.0/T抄録全体を表示PDF形式でダウンロード (688K) -
ポリエチレングリコール及びカーボワッのクス類中の水分簡易定量法石黒 武雄, 松本 克1955 年 75 巻 11 号 p. 1418-1419
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーTate's entrainer method was utilized to determine moisture in polyethylene glycols and carbowax compounds. As the entrainer, benzene, toluene, and xylene were examined and it was found that benzene and toluene would be suitable because they entrain up to 99.7% moisture while xylene entrains only about 90%. The time required until the maximum entrainment of moisture was over 150minutes with toluene and over 240minutes with benzene.抄録全体を表示PDF形式でダウンロード (327K) -
筒井 清, 河原 清, 藤田 昭夫1955 年 75 巻 11 号 p. 1419-1421
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーIt was shown that N1-acyl-4-acetylaminonaphthalenesulfonamide-1 could be prepared by the Schotten-Baumann reaction of 4-acetylaminonaphthalenesulfonamide-1 in alkali hydroxide solution with acylation agent, such as acid anhydride or acyl chloride.抄録全体を表示PDF形式でダウンロード (534K) -
鵜木 諄1955 年 75 巻 11 号 p. 1421-1423
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーThe crude 3-(2-methyl-4-amino-5-pyrimidylmethyl)-4-hydroxy-4-methyl-5-β-chloroethylthiazolidine-2-thione (III), obtained by the treatment of γ-aceto-γ-chloropropyl chloride (I) and 2-methyl-4-amino-5-aminomethylpyrimidine (II) with carbon disulfide, in the presence of ammonia, was separated and purified as the hydrochloride sparingly soluble in water and the treatment of (III) with alkali also afforded it in a pure state. The properties of this compound were examined.抄録全体を表示PDF形式でダウンロード (590K) -
1-Chlorophthalazine及びQuinazolineの合成足立 亀久夫1955 年 75 巻 11 号 p. 1423-1426
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーThe known synthetic methods for 1-chlorophthalazine and quinazoline were examined and none of them were found satisfactory. Good results were obtained by the following modified process.
1) Naphthalene was oxidized with potassium permanganate to phthalonic acid, its ketocarboxylic acid solution was reacted with hydrazine to 1-phthalazone-4-carboxylic acid, and its decarboxylation afforded 1-phthalazone in a good yield. Its chlorination by the usual method gave 1-chlorophthalazine in a good yield.
2) o-Nitrotoluene was oxidized with freshly formed mercury oxide to o-nitrobenzaldehyde in a good yield, derived to o-nitrobenzaldiformamide, and its reduction with iron and hydrochloric acid afforded quinazoline in a good yield. Reduction with zine and acetic acid by the known method afforded only a minute amount of quinazoline besides indazole.抄録全体を表示PDF形式でダウンロード (647K) -
Benzodiazine誘導体のエーテル交換分解反応足立 亀久夫1955 年 75 巻 11 号 p. 1426-1429
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーTransetherification reactions of benzodiazine and benzothiazole derivaties were carried out with ethanol and isopropanol. It was found that such transetherification is possible in quinazoline, cinnoline, phthalazine, and benzothiazole derivatives. Such transetherification does not occur in quinoline and isoquinoline rings, and quinoxazaline underwent transetherification in a degree intermediate of the foregoing two kinds of substances.抄録全体を表示PDF形式でダウンロード (535K) -
大熊 誠一1955 年 75 巻 11 号 p. 1430-1431
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリー1) Detection of m-dinitrophenyl compounds by acetone and sodium hydroxide, and color reaction of reducive organic compounds by o-dinitrobenzene were examined.
2) Detection of phenyl radical, indirectly, by nitration of phenyl compounds and coloration of the polynitrophenyl compounds thereby formed with acetone and sodium hydroxide or glucose and sodium hydroxide, were examined.抄録全体を表示PDF形式でダウンロード (316K) -
アンチピリン誘導体について その1高橋 酉藏, 岡田 壽太郎, 堀 幹夫1955 年 75 巻 11 号 p. 1431-1434
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーBy the application of α-chloropropionyl chloride, α-bromopropionic anhydride, or 4-halopropionic acid (or its ester) to 4-aminoantipyrine, 4-halopropionylamino derivatives were prepared. Condensation of mono- or dimethylamine to these derivatives afforded 4-α-mono (or di) methylaminopropionylaminoantipyrines. Reaction of 4-aminoantipyrine with hydrochloride or esters of α-dimethylaminopropionic acid under the presence of phosphorus pentoxide also afforded the 4-α-dimethylaminopropionylaminoantipyrine. By the application of α-halopropionyl halides or α-bromopropionic anhydride to 4-methylaminoantipyrine, 4-methyl-4-α-halopropionyl derivatives were prepared and these were condensed with mono- and dimethylamine to afford 4-methyl-4-α-mono (and di) methylpropionylaminoantipyrines.抄録全体を表示PDF形式でダウンロード (602K) -
ヒノリン誘導体について その1高橋 酉藏, 濱田 喜樹1955 年 75 巻 11 号 p. 1434-1436
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリー2-Methoxy (or ethoxy)-6-nitrobenzamide was derived to 2-methoxy (or ethoxy)-6-nitrobenzoic acid by the application of sodium nitrite and sulfuric acid. Reaction of 2-methoxy-6-aminobenzoic acid and nitroacetaldoxime, in hydrochloric acid solution, afforded 2-methoxy-6-(β-nitroethylidene) aminobenzoic acid, whose cyclization gave 3-nitro-4-hydroxy-5-methoxyquinoline. Decomposition of 2-cyanoquinolines in acetone, by the Radziszewsky method, afforded the corresponding acid amides in a good yield.抄録全体を表示PDF形式でダウンロード (449K) -
コシダのフラボノール配糖体岸本 安生1955 年 75 巻 11 号 p. 1437-1439
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーMethanol extract of the terrestrial portion of Dicranopteris dichotoma Bernh. was treated by the usual method and quercitrin (quercetin 3-rhamnoside) was obtained from the precipitate formed from methanol by lead acetate, and afzelin (kaempferol 3-rhamnoside) from its mother liquor. Both were identified by hydrolysis, determination of the position of the sugars, and physical properties.抄録全体を表示PDF形式でダウンロード (502K) -
高田 善之, 高田 善宏1955 年 75 巻 11 号 p. 1439-1440
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーBy heating an aqueous solution of sodium nonanoylhydrazinomethanesulfonate, dinonanoylhydrazine, m.p. 151.5°, was obtained. In general, sodium acylhydrazinomethanesulfonate, RCONHNHCH2SO3Na (R=alkyl), undergoes decomposition when heated in aqueous solution and forms diacylhydrazine.抄録全体を表示PDF形式でダウンロード (314K) -
竹本 常松, 西本 喜重, 廻 治雄, 片山 和子1955 年 75 巻 11 号 p. 1441-1442
発行日: 1955/11/25
公開日: 2010/02/19
ジャーナル フリーPDF形式でダウンロード (272K)
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