第2級アミンの新合成法 (第6報)

β-メチルアミノ-α-フェニルプロパン及びγ-メチルアミノ-α-フェニルブタンの合成

抄録

α-Methylphenethyl and α-methylphenylpropyl bromides or tosylates easily undergo decomposition but will undergo condensation with saccharin when dimethylformamide is used as a solvent. By the successful conclusion of this first step, preparation of β-methylamino-α-phenylpropane and γ-methylamino-α-phenylbutane by the saccharin method became possible. The final process of acid hydrolysis can be effected by boiling with conc. hydrochloric acid under an ordinary pressure but the reaction is more sluggish than in the case of a straight chain phenethyl group.