エンテリックコーティングの研究 (第5報)

Methylcellulose Dihydrogen Dicarbonates並びにEthylhydroxyethylcellulose Dihydrogen Dicarbonatesについて

抄録

As the monoesters of dibasic acids of methylcellulose and ethylhydroxyethylcellulose, methylcellulose hydrogen phthalate (I) and hydrogen succinate (II), and ethylhydroxyethylcellulose hydrogen phthalate (III) and hydrogen succinate (IV) were prepared in order to examine their utility as an enteric coating agent. It was thereby found that (I) and (III) were extremely good enteric coating agents as evidenced by successful attainment of the objective by coating in the usual manner in a coating pan the ethylene dichloride and ethanolic or chloroform and ethanolic solution of (I) and (III), or acetone and ethanolic solution of (III). However, (II) and (IV) were found to be practically insoluble in organic solvents, that their coating was effected by preparing an aqueous solution of the methylcellulose and ethylhydroxyethylcellulose sodium succinate. (IV) was found to be possible in using as an enteric coating but (II) was found to swell by moisture and unsuitable as an enteric coating agent.