チアツォール誘導体の研究 (第8報)

Dithiazolyl sulfide誘導体の合成 その1

抄録

Application of hydrogen peroxide to 2-mercapto-4-methyl-5-hydroxyethylthiazole and 2-mercapto-4-methyl-5-acetoxyethylthiazole, in the presence of hydrochloric acid, yields 4-methyl-5-hydroxyethylthiazole, while the use of conc. hydrochloric acid gives 2-chloro-4-methyl-5-hydroxyethylthiazole as a by-product. In case the amount of hydrogen peroxide is not enough, bis (4-methyl-5-hydroxyethylthiazolyl-2) sulfide is formed besides the foregoing. The last-named was confirmed by its synthesis from 2-chloro-4-methyl-5-hydroxyethylthiazole and 2-mercapto-4-methyl-5-hydroxyethylthiazole.