Vitamin B₁及び諸関係化合物の研究 第78報

Thiamine-Thiazolone同族体のプロム化反応

抄録

Bromination of thiaminethiazolone (I) afforded a monobromo derivative, assumed to be 3-(2-methyl-4-aminol-5-pyrimidinylmethyl)-3a-methyl-6a-bromotetrahydrofuro-[2, 3-d]thiazolin-2-one (IV). Both thiaminethiazolone acetate (V) and its 5-methyl homolog (VI) form a compound not containing bromine but one oxygen more than the original compounds by the action of bromine and the compound is assumed to be a 4, 5-epoxy compound (VI and VII).