テトラリン誘導体の合成並びに薬理学的研究 (第3報)

抄録

5-Phenyl-5-(β-tetralyl) hydantoin (III), -3-methylhydantoin (IV), -thiohydantoin (V), and -3-methylthiohydantoin (VI) were prepared and their anticonvulsant action (electric shock and Pentetrazol) was examined with the corresponding 5-diphenyl derivatives as the control. These compounds were inferior to 5, 5-diphenylhydantoin and did not show any convulsant action except (V), which only suppressed electric shock in doses above that of LD₅₀.