Vitamin B₁及び諸関係化合物の研究 第74報

Pyrimidine誘導体の合成研究 その3 Pyrimidine誘導体の赤外線吸収スペクトル

抄録

Infrared absorption spectral analyses of the pyrimidine derivatives reported in the preceding paper revealed the following facts. The 4-aminopyrimidine derivatives without a piperidinomethyl group in the 5-position shows a normal absorption of the primary amine in a carbon tetrachloride solution, while the absorption of the primary amine of the 4-amino group in the 4-amino-5-piperi-dinomethyl derivative, in carbon tetrachloride solution, shifts to a longer wave length region by the intramolecular hydrogen bonding. The absorption spectrum has endorsed the structure of the bis (piperidinomethyl) compound of 2-methyl-4-amino-6-hydroxypyrimidine, which had been assumed as 2-methyl-4-piperidino-methylamino-5-piperidinomethyl-6-hydroxypyrimidine. The absorption band of OH at 3000-2700cm^-1 in 6-hydroxypyrimidine derivatives was observed at 2200-2100cm^-1 by deuterium substitution from which it was assumed that the compound is present as a dimer, indicated in Fig. 5 (a).